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Posted Apr 17, 2026

[Remote] Software Engineer - .NET Full Stack Developer

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Note: The job is a remote job and is open to candidates in USA. Mayo Clinic is a top-ranked healthcare provider dedicated to patient care and employee support. They are seeking a Software Engineer to design, develop, and maintain .NET-based back-end services for genomics and clinical applications, ensuring performance and reliability while collaborating with cross-functional teams. Responsibilities - Design, develop, and maintain robust .NET-based back-end services supporting a broad portfolio of genomics and clinical applications - Build and optimize services that handle complex genomic workflows, large-scale clinical datasets, and high-throughput data processing - Ensure that all services meet strict performance, reliability, and accuracy requirements, scale effectively as data volumes grow, and remain resilient within hybrid cloud ecosystems - Collaborate closely with Product Owners, Product Managers, Architects, and cross-functional engineering partners to translate requirements into well-architected, maintainable code - Design and implement services aligned to enterprise architecture, including cloud-ready APIs, data integration pipelines, and secure interoperability layers for genomic systems - Participate in Agile and DevOps practices using GitHub, Azure DevOps (ADO), Azure Pipelines, and CI/CD frameworks - Work may include deployment automation and configuration management using tools such as ARM/Bicep, Terraform, Cloud Build, or Azure Pipelines, supporting both on-prem and cloud-hosted applications - Maintain comprehensive technical documentation, contribute to code reviews, and participate in expert-level troubleshooting through log analysis, root cause evaluation, and data/system investigation - Communicate effectively with peers, leaders, and clinical partners across the organization - Build knowledge of genomics workflows, organizational processes, and customer needs while performing a range of technical assignments with moderate guidance and increasing autonomy Skills - Bachelor's degree in computer science/engineering or related field; Or an associate's degree in computer science/engineering or related field with an additional 2 years of experience as described below - Have working knowledge and experience of Software Engineering with a minimum of internships and a minimum of 1 year of experience, or 2 years of experience coding applications or services in a high-level language (C, C++, Golang, Java, C# etc.) - Demonstrated problem solving and time management skills - Possesses strong technical aptitude for designing and implementing software solutions - Experience with modern application development frameworks - Knowledge of professional software engineering practices & best practices for the full software development life cycle, including coding standards, code reviews, source control management, build processes, testing, and operations - Deep hands-on technical expertise, excellent verbal and written communication skills - Experience with Agile software development techniques - Experience developing applications in hybrid environments, including on-premises systems, Azure, and Google Cloud Platform (GCP) - Familiarity with building and integrating RESTful APIs, microservices, and web services using .NET technologies - Knowledge of DevOps pipelines and CI/CD using Azure DevOps, GitHub Actions, or Azure Pipelines - Utilization of AI coding tool such as GitHub CoPilot, Gemini, Claude - Experience with relational and NoSQL databases, analytics platforms, big-data processing, or enterprise data pipelines - Background in developing high-performance, scalable, and highly available distributed systems - Experience supporting or developing solutions in healthcare, clinical, Bioinformatics or genomics-focused applications is highly desirable - Ability to use a wide variety of open-source technologies and cloud-based services - Experience with Google and Azure cloud environments - Experience in databases, analytics, big data systems or business intelligence products - Experience with building high-performance, highly available and scalable distributed systems - Experience developing software for healthcare related industries Benefits - Medical: Multiple plan options. - Dental: Delta Dental or reimbursement account for flexible coverage. - Vision: Affordable plan with national network. - Pre-Tax Savings: HSA and FSAs for eligible expenses. - Retirement: Competitive retirement package to secure your future. Company Overview - MayoClinic is a nonprofit medical practice and medical research group focused on integrated health care, education, and research. It was founded in 1864, and is headquartered in Rochester, Minnesota, USA, with a workforce of 10001+ employees. Its website is https://www.mayoclinic.org.
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